Welcome

 Marcelo Fernandez-Viña

Dear Colleagues,

Welcome to the official website of the 17th International HLA and Immunogenetics Workshop (IHIWS). The tradition of the International HLA and Immunogenetics Workshop is strong and compelling. Sixteen prior workshops have provided the opportunity and momentum for major technological and scientific progress.

The 17th Workshop promises to further advance the continued international collaboration in research in HLA and Immunogenetics projects. The major goals are to define HLA and KIR genomics and map serologic epitopes using NGS, SNP, and single antigen bead technologies, and to develop robust research and clinical informatics tools for HLA and KIR.

We hope you will join us at the 17th International HLA and Immunogenetics Workshop to be held at the Asilomar Conference Grounds in Pacific Grove, California, September 6 – 10, 2017. This will be followed by the American Society of Histocompatibility and Immunogenetics (ASHI) 44th Annual Meeting September 11 – 15, 2017 in San Francisco, California.

Please set aside these important dates in 2017. We hope to see you in the San Francisco Bay Area during this time. Apply to participate and keep up with the latest developments by signing up for email updates.

 

Yours Sincerely,

 Marcelo Fernandez-Viña, Chair


Workshop Description

The 17th IHIWS will study HLA and KIR genomics, define full length MHC sequences, map serologic epitopes and develop robust informatics for HLA and KIR research through the use of NGS and SNP technologies, single antigen beads (SAB) and flow cytometry.

The 17th IHIWS projects will fall under the following components:

(Click on the component name for more information)

Single Nucleotide Polymorphism (SNP) Analysis of MHC and KIR Mapping of Serologic Epitopes Hematopoietic Cell Transplantation (HCT) Quality Control & Quality Assurance Informatics of Genomic Data NGS of Full-length KIR Genes NGS of Full-length HLA genes

Latest Developments (Read All)

Extension of HLA allele sequences by full-length HLA allele-specific hemizygous Sanger sequencing (SSBT)

The Human Leucocyte Antigen (HLA) is one of the most polymorphic gene systems present in the human genome and due to this high polymorphism, the golden standard for typing at the allele level has been and still is sequence based typing. Since sequencing strategies have mainly focused on identification of... Read More

NGS of Full-length HLA genes NGS of Full-length HLA genes

The HLA genes are the most polymorphic loci in the human genome; over 12,000 genetic variants (alleles) have been identified at 19 HLA genes, with some individual genes displaying several thousand alleles. The allelic and structural variation that characterizes these genes pose extreme challenges for routine genotyping of these genetic... Read More

NGS of Full-length KIR Genes NGS of Full-length KIR Genes

Goals:

  • Characterize the nature and extent of KIR allelic diversity across human populations using Next Generation Sequencing (NGS).
  • Perform high-resolution KIR genotyping in families from diverse populations in order to define phased KIR haplotypes through segregation analysis.
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    Although hundreds of populations have been investigated for KIR gene content diversity,... Read More

    Mapping of Serologic Epitopes Mapping of Serologic Epitopes

    Studies in this component of the workshop will be focused on defining HLA serologic epitopes contributing to antibody mediated rejection in renal and cardiac transplant recipients (because the pathology is best worked out in these groups).

    Background:

    The widespread use of highly sensitive and specific solid phase assays for... Read More