Welcome

Asilomar — Crocker Hall

Preparing for Your Visit

Dear 17th IHIWS Participants,

Thank you for registering for the 17th International HLA & Immunogenetics Workshop. We look forward to seeing you in Monterey! The current agenda is posted here. Below are some reminders & updates to keep in mind before you arrive.

Workshop Location: The workshop is taking place at the Asilomar Conference Grounds in Pacific Grove, CA.  The address is: 800 Asilomar Ave, Pacific Grove, CA 93950. See the Asilomar website for more details about the conference grounds. For a map of the Asilomar meeting space, please click here.

Registration Location & Welcome Reception: Registration will be open from 3:00-7:00 PM on Wednesday, Sept. 6 in Merrill Hall near the lodging check-in. The welcome talk & reception will occur after dinner from 7:00-9:30 PM in Merrill Hall. Come meet your fellow attendees at the reception and enjoy light bites and beverages. We ask that all attendees pick up their name badge and keep it on at all times during the workshop so that staff can tell you are part of the group.

Registration/Information Desk: The registration desk will be located in Merrill Hall on Thursday from 7:30-3:30pm and Fri-Sun from 8am-3pm. The desk will be closed from 12:00-1:00 PM each day during the lunch break.

Getting to Asilomar Conference Grounds

  • Check out the Asilomar Travel & Directions page for links to maps and public transit.
  • Monterey Airbus provides shuttle airport transportation to and from San Jose Mineta Airport (SJC) and San Francisco Airport (SFO). You can book online at: https://www.montereyairbus.com/
  • Ground Transportation information, including rental car information is located here:

http://ihiws.org/travel/

Parking: Complimentary self-parking is available at Asilomar.

Speakers: Please check the current agenda posted online to confirm your speaking time & location (there may be updates)!

Weather / Attire: The average forecasted temperature in the Monterey Bay area for early September is 53º-70ºF (Weather.com information). Please note: Monterey mornings and nights can be cold, windy & foggy. As the meeting rooms are spread out on the grounds, and this event will occur both inside and outdoors, we strongly encourage dressing in layers. “California casual” is acceptable for all workshop and evening activities. We recommend comfortable walking shoes. Sunglasses, sunscreen, umbrellas and hats are optional, useful items. A warm sweater or jacket and a warm hat are highly suggested for evenings!

Meals: If you are staying at Asilomar, your meals are included with your lodging in the Crocker Dining Hall. Coffee & refreshment breaks will be located in Merrill Hall and are included for all workshop attendees. The Saturday evening closing “strolling dinner” will take place outside in the Asilomar BBQ & Meadow area.

Internet Access: WiFi is complimentary in both the guest rooms and meeting rooms at Asilomar. If you plan to bring a laptop, please note that there are few power outlets within the facility; we recommend bringing extra batteries.

Printing: We will have one self-service printing, copy & fax station for workshop attendees to use at no charge, located in Merrill Hall, next to the registration desk. There is an additional business center located in the Asilomar Social Hall where guests can print & make copies (pay per use).

Social Events

  • Wine Tasting – Friday, Sept 8 (7:30pm – 9:30pm) SeaScape Room
    Enjoy tasting award-winning Monterey County wine varietals after dinner with “A Taste of Monterey.” These wines are examples of some of the finest wines in the state.
  • Closing Dinner & Party – Saturday, Sept 9 (7:00pm – 10:00pm)
    The closing dinner & celebration will take place outdoors in the Asilomar BBQ & Meadow area. Enjoy a strolling dinner of Monterey and Californian specialties and the sunny, feel good tunes of our California beach band “Wild Blue.” Each attendee will receive two drink tickets for this event tucked in their name badge. NOTE: Event will take place outdoors and it can get chilly near the beach~ please dress warmly!
  • Post-Workshop Shuttle Transportation to San Francisco (ASHI – Hilton SF Union Square)
  • Attendees who have purchased a ticket: Shuttles to San Francisco will depart outside Merrill Hall @ 5:30pm on Sunday, 9/10
  • Councilors: There will be one shuttle designated for Councilors departing @ 5:30pm on Sunday, 9/10. This shuttle will transport Councilors to dinner and then continue on to San Francisco (ASHI – Hilton SF Union Square).
  • Sightseeing – For those with extra time to explore the area, check out the Monterey County Convention & Visitors Bureau website for local attractions or find out where to go in San Francisco on the San Francisco Travel

 

We look forward to seeing you soon!

Sincerely,
17th IHIWS Organizing Committee

 


Download the Event App

Please download the mobile event app before you arrive so that you can view the complete agenda and access maps & workshop information: http://hca.io/e/y7uc6y or use the QR code to download to your phone via your app store.


Components & Projects

The 17th IHIWS will study HLA and KIR genomics, define full length MHC sequences, map serologic epitopes and develop robust informatics for HLA and KIR research through the use of NGS, single antigen beads (SAB) and flow cytometry.

The 17th IHIWS projects will fall under the following components:

(Click on the component name for more information)

All Serologic Epitopes Projects All NGS of Full-length HLA Genes Projects NGS of Full-length KIR Genes Mapping of Serologic Epitopes Hematopoietic Cell Transplantation (HCT) Quality Control & Quality Assurance Informatics of Genomic Data NGS of Full-length HLA genes

Latest Developments (Read All)

NGS of Full-length HLA genes NGS of Full-length HLA genes -

The HLA genes are the most polymorphic loci in the human genome; over 12,000 genetic variants (alleles) have been identified at 19 HLA genes, with some individual genes displaying several thousand alleles. The allelic and structural variation that characterizes these genes pose extreme challenges for routine genotyping of these genetic loci; this variation cannot be characterized by a few SNPs, and the high level of polymorphism confounds de novo sequence assembly efforts. Until recently, HLA genotyping has been accomplished using a variety of PCR-based approaches involving sequence-specific oligonucleotide probe (SSOP) hybridization and/or Sanger sequencing of 400-600 base pair amplicons. These... Read More

Component: NGS of full length HLA genes: Preliminary results of the Pilot Study -

Lisa E Creary1, Steven J Mack2 and Marcelo Fernandez-Vina1
1Department of Pathology, Stanford Blood Center
2Children’s Hospital Oakland Research Institute

Overview

The ultimate goal of the 17th International HLA and Immunogenetics Workshop (IHIW) is to advance the fields of Histocompatibility and Immunogenetics (H & I) research through the application of Next-Generation Sequencing (NGS) technologies for HLA and KIR genotyping, and to advance the development of NGS technologies tailored to meet the needs of the H & I community.

In 2014, we initiated an international multi-center pilot study in order to assess the performance of various NGS protocols, platforms,... Read More

T Cell Receptor (TCR)-HLA Interaction -

The T cell receptor is the natural receptor of the HLA-peptide complex and interacts directly with MHC molecules, notably their CDR regions.  The goal of this project will be to combine analysis of TCR and HLA in the context of disease, vaccination/immune alterations and populations.  We would expect samples to be CD4 or CD8 T cells and to have full HLA class I and class II typing by NGS.

Required NGS HLA loci: HLA-A, B, C, DRB1, DRB3/4/5, DQB, HLA-DQA, DPA, DPB
Optional NGS HLA Loci: MICA, MICB

Subprojects for this component will include:
  • Disease study:  This will involve... Read More
  • Extension of HLA allele sequences by full-length HLA allele-specific hemizygous Sanger sequencing (SSBT) -

    The Human Leucocyte Antigen (HLA) is one of the most polymorphic gene systems present in the human genome and due to this high polymorphism, the golden standard for typing at the allele level has been and still is sequence based typing. Since sequencing strategies have mainly focused on identification of the peptide binding groove, therefore the majority of HLA alleles lack full length sequence information.

    The goal of this project is to extend the sequences of as many incompletely covered HLA alleles as possible by full length unambiguous Sanger Sequencing. Although NGS approaches are currently implemented in several laboratories, many... Read More


    Recent Events

    database vendor summit

    17th IHIWS Vendor Summit
    SEPTEMBER 25, 2016
    ST. LOUIS, MO

    During this Summit, we had presentations from Kazutoyo Osoegawa PhD, Stanford HIDPL, who described the Data entry experience from various participants into the IHIWS database, demonstrating the need for standarized reporting.

    We also heard from Steve Mack PhD, CHORI, whose presentation provided an overview of the workshop and specifically the database, highlighting the need to have uniform Data content and why all NGS data and meta-data should be compatible and comparableallowing all formats to be equally interpretable during analysis. Steve described the concept of Minimum Information for Reporting Immunogenomic NGS Genotyping (MIRING) and why it is essential to analysis to be performed on the data collected.

    Last, we heard from Bob Milius PhD, Bioinformatics Research NMDP®/Be The Match®. Bob presentation focused on MIRING & HML reporting as well as XML schemas. In a second presentation, Bob described Genome Sequence Coordinates, advantages and disadvantages of One-Based Vs. Zero-Based systems and matching SequenceBlock to the reference sequence.

     

    Read more / View the presentations